Endocrine Abstracts

Introduction: Mountain dwellers show a lower prevalence of diabetes, which among countless other factors could be due to lower partial oxygen pressure at high altitude. The present study was to investigate in an experimental setting, if and how reduced oxygen availability affects blood glucose.Methods: Male obese mice on high fat diet were continuously maintained under a normobaric hypoxic atmosphere (10% oxygen) for three months. To exclude indirect eff...

Sleep apnea (SA) is a common acromegaly comorbidity, influencing patients’ quality of life and mortality risk. Despite its importance, SA frequently remains undiagnosed, and its real prevalence seems to be underestimated. The current observational study aimed at investigating the role of Berlin questionnaire (BQ) and Epworth sleepiness scale (ESS) in assessing the risk of SA in this high-risk population, and to compare the results with an age-and gender-matched health coh...

The concurrence of glucose intolerance, hypertension, dyslipidemia and obesity has been termed metabolic syndrome. Each component of the metabolic syndrome is an independent risk factor for cardiovascular disease and diabetes type 2, the combination of these risk factors elevating the rates and severity of cardiac pathology.The therapeutic use of irbesartan, a selective blocker of the AT1 receptors, administered in arterial hypertension, coronary heart d...

Introduction: The prevalence of acromegaly is estimated to be 6-28/100000 but several studies suggest that acromegaly is underdiagnosed and its prevalence is underestimated.Aim: To measure the prevalence of clinically relevant acromegaly in a well-defined population using data from 01.04.2004 to 01.11.2016.Method: Cross-sectional study performed in 8 counties from the North-East Romania. Data of patients with acromegaly were collec...

Background: HIV-associated hypogonadism is a prevalent endocrine disorder, total testosterone (TT) test is not useful for its diagnosis, Endocrine Society clinical practice guidelines have recently proposed calculated free testosterone (FT) as screening test of hypogonadism in HIV infected men, but no clinical study has been published using this approach in HIV population to date. Our aim was to study prevalence and risk factors for hypogonadism in HIV-infected men using FT.</...

Background: GI neuroendocrine tumors express somatostatin (SSTR) receptors, and the radioloabeled SSTR analog Lu-177-DOTATATE is an FDA-approved systemic treatment for those with metastatic disease. Olaparib is a poly (ADP-ribose) polymerase inhibitor (PARPi) which inhibits cells from repairing damaged DNA, especially single-stranded DNA breaks caused by beta particle emissions from the radioactive decay of Lu-177. We report the first results of a phase 1/2 study evaluating th...

Background: Metastatic GI Neuroendocrine Tumors (GI-NET) and pheochromocytoma/paraganglioma (PPGL) are are tumors which overexpresses somatostatin receptors (SSTR) and can be treated with targeted radioligand therapy (RLT) such as Lu-177-DOTATATE. However, despite demonstrated clinical efficacy at stabilizing tumor growth, durable response is very rare and almost all patients inevitably progresses at some time after treatment. Good systemic therapy options after beta-emiting R...

Introduction: Even mild to moderate maternal iodine deficiency during pregnancy is associated with impaired child cognition. Iodine deficiency is especially problematic in pregnant women, who have a higher iodine requirement (250 μg/day) than non-pregnant women (150 μg/day).Objective: To assess iodine status (median urinary iodine concentration, UIC) in pregnant women from multiple endemic or non-endemic areas in Romania, 13 years after impleme...

Thyroid disease is common among the population, and the prevalence increases with age. In patients with type 1 diabetes mellitus (T1DM) the risk of thyroid dysfunction and thyroid autoimmunity is increased. The aim of this study was to investigate the relationship between thyroid function and T1DM duration. There were evaluated 110 patients (71 women and 39 men) with T1DM between 2013 and 2015 and were appreciated antibodies against thyroid peroxidase (ATPO) (normal values...

Background: Pheochromocytoma (PHEO) is a rare neuroendocrine tumor arising from chromaffin cells of adrenal gland that can cause life-threatening complications due to overproduction of catecholamines. Per EANM/SNMMI 2019 guidelines for radionuclide imaging of PHEO and paraganglioma, 18F-fluoro-L-dihydroxyphenylalanine (18F-FDOPA) is recommended as a positron emission tomography (PET) radiotracer of choice followed by 68Ga-DOTA(0)-Tyr(3)-octreot...